mouse LRP4 Adenovirus
This is an Adenovirus expressing Mouse Lrp4.
ADV-263815
Ad-m-LRP4
Ready-to-use Adenovirus expressing Mouse Lrp4 (low density lipoprotein receptor-related protein 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
6430526J12Rik; D230026E03; mdig; Megf7
Description (Vector)
Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.
Gene ID
228357
Gene Name (Vector)
low density lipoprotein receptor-related protein 4
Gene Symbol
Lrp4
ORF Size (aa)
5718
ORF Size (bp)
5718 bp
RefSeq ID
NM_172668
RefSeq Synonyms
NM_172668, NM_001145857, BC132240,
Species
mouse
UniGene ID
Mm.469960
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.