mouse ECT2 Adenovirus
This is an Adenovirus expressing Mouse ECT2.
ADV-257737
Ad-m-ECT2
Ready-to-use Adenovirus expressing Mouse Ect2 (ect2 oncogene). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI528536; mKIAA4037
Description (Vector)
Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Gene ID
13605
Gene Name (Vector)
ect2 oncogene
Gene Symbol
Ect2
ORF Size (aa)
2649
ORF Size (bp)
2649 bp
RefSeq ID
NM_007900
RefSeq Synonyms
NM_007900, NM_001177626, NM_001177625, BC045614, BC032155, BC025565, BC023881,
Species
mouse
UniGene ID
Mm.261453
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.