mouse BTBD12 Adenovirus
This is an Adenovirus expressing Mouse BTBD12.
ADV-254127
Ad-m-BTBD12
Ready-to-use Adenovirus expressing Mouse Slx4 (SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI256635; AI426760; Btbd12; D16Bwg1016e
Description (Vector)
Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.
Gene ID
52864
Gene Name (Vector)
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Gene Symbol
Slx4
ORF Size (aa)
4698
ORF Size (bp)
4698 bp
RefSeq ID
NM_177472
RefSeq Synonyms
NM_177472, BC065125,
Species
mouse
UniGene ID
Mm.29935
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.