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human BRAP Over-expression AAV

Name 
AAV-h-BRAP
Cat No 
AAV-202249
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human BRAP.

AAV-202249
AAV-h-BRAP

Ready-to-use AAV expressing Human BRAP (BRCA1 associated protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BRAP2; BRCA1-associated protein; galectin-2-binding protein; IMP; impedes mitogenic signal propagation; renal carcinoma antigen NY-REN-63; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2; RNF52
Description (eCommerce)
BRCA1-associated protein (BRAP) negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. BRAP acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. BRAP may also act as a cytoplasmic retention protein with a role in regulating nuclear transport [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q7Z569].
Description (Vector)
BRAP was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm.
Gene ID
8315
Gene Name (eCommerce)
BRCA1 associated protein
Gene Name (Vector)
BRCA1 associated protein
Gene Symbol
BRAP
HGNC ID
HGNC:1099
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1779
ORF Size (bp)
1779 bp
Protein Name (eCommerce)
BRCA1-associated protein
RefSeq ID
NM_006768
RefSeq Synonyms
NM_006768, BC136699, BC136698,
Research Areas
MAPK Signaling,Signal Transduction,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
BRCA1-associated protein (BRAP) negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. BRAP acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. BRAP may also act as a cytoplasmic retention protein with a role in regulating nuclear transport [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q7Z569].
UniGene ID
Hs.530940
UniProt ID (eCommerce)
Q7Z569

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.