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human BLNK Over-expression AAV

Name 
AAV-h-BLNK
Cat No 
AAV-202166
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human BLNK.

AAV-202166
AAV-h-BLNK

Ready-to-use AAV expressing Human BLNK (B-cell linker). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AGM4; BASH; bca; BLNK-S; LY57; SLP-65; SLP65
Description (Vector)
BLNK encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.
Gene ID
29760
Gene Name (Vector)
B-cell linker
Gene Symbol
BLNK
HGNC ID
HGNC:14211
ORF Size (aa)
1371
ORF Size (bp)
1371 bp
RefSeq ID
NM_013314
RefSeq Synonyms
NM_013314, NM_001258442, NM_001258441, NM_001258440, NM_001114094, BC018906,
Species
human
UniGene ID
Hs.665244

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.