mouse ADAR Adenovirus
This is an Adenovirus expressing Mouse Adar.
ADV-252106
Ad-m-ADAR
Ready-to-use Adenovirus expressing Mouse Adar (adenosine deaminase, RNA-specific). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Adar1; Adar1p110; Adar1p150; AV242451; mZaADAR
Description (Vector)
Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression.
Gene ID
56417
Gene Name (Vector)
adenosine deaminase, RNA-specific
Gene Symbol
Adar
ORF Size (aa)
3459
ORF Size (bp)
3459 bp
RefSeq ID
NM_019655
RefSeq Synonyms
NM_019655, NM_001146296, NM_001038587, BC042505,
Species
mouse
UniGene ID
Mm.316628
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.