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human BARD1 Over-expression AAV

Name 
AAV-h-BARD1
Cat No 
AAV-201963
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human BARD1.

AAV-201963
AAV-h-BARD1

Ready-to-use AAV expressing Human BARD1 (BRCA1 associated RING domain 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BARD-1; BRCA1-associated RING domain gene 1; BRCA1-associated RING domain protein 1; RING-type E3 ubiquitin transferase BARD1
Description (eCommerce)
BRCA1 associated RING domain 1 (BARD1) together with BRCA1 is an E3 ubiquitin ligase. BARD1/BRCA1 has been shown to ubiquinate RNA polymerase II in response to DNA damage. BARD1/BRCA1 ubiquitin ligase activity has also been shown to be important in the prevention of double stranded breaks and the regulation of centrosome number.
Description (Vector)
BARD1 encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
Gene ID
580
Gene Name (eCommerce)
BRCA1 associated RING domain 1
Gene Name (Vector)
BRCA1 associated RING domain 1
Gene Symbol
BARD1
HGNC ID
HGNC:952
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2334
ORF Size (bp)
2334 bp
Protein Name (eCommerce)
BRCA1-associated RING domain protein 1
RefSeq ID
NM_000465
RefSeq Synonyms
NM_001282549, NM_001282548, NM_001282545, NM_001282543, NM_000465, BC126428, BC126426,
Research Areas
Apoptosis,Breast Cancer,Cancer,Cell Cycle,DNA Damage/Repair,Homologous Recombination,mRNA Splicing,Nuclear Import/Export,Prostate Cancer,RNA Binding,RNA Processing,Signal Transduction,Spermatogenesis,Transport,Tumor Suppressors/Oncoproteins,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
BRCA1 associated RING domain 1 (BARD1) together with BRCA1 is an E3 ubiquitin ligase. BARD1/BRCA1 has been shown to ubiquinate RNA polymerase II in response to DNA damage. BARD1/BRCA1 ubiquitin ligase activity has also been shown to be important in the prevention of double stranded breaks and the regulation of centrosome number.
UniGene ID
Hs.591642
UniProt ID (eCommerce)
Q99728

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.