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human BACE2 Over-expression AAV

Name 
AAV-h-BACE2
Cat No 
AAV-201931
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human BACE2.

AAV-201931
AAV-h-BACE2

Ready-to-use AAV expressing Human BACE2 (beta-site APP-cleaving enzyme 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
Description (Vector)
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.
Gene ID
25825
Gene Name (Vector)
beta-site APP-cleaving enzyme 2
Gene Symbol
BACE2
HGNC ID
HGNC:934
ORF Size (aa)
1557
ORF Size (bp)
1557 bp
RefSeq ID
NM_012105
RefSeq Synonyms
NM_138992, NM_138991, NM_012105, BC014453,
Species
human
UniGene ID
Hs.529408

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.