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human AKAP9 Adenovirus

Name 
Ad-h-AKAP9
Cat No 
ADV-232889
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human AKAP9.

ADV-232889
Ad-h-AKAP9

Ready-to-use Adenovirus expressing Human AKAP9 (A-kinase anchoring protein 9). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
A kinase (PRKA) anchor protein (yotiao) 9; A kinase (PRKA) anchor protein 9; AKAP 120-like protein; AKAP 350; AKAP 450; AKAP350; AKAP450; AKAP-9; AKAP9-BRAF fusion protein; A-kinase anchor protein 350 kDa; A-kinase anchor protein 450 kDa; A-kinase anchor protein 9; centrosome- and Golgi-localized PKN-associated protein; centrosome- and golgi-localized protein kinase N-associated protein; CG-NAP; hgAKAP 350; HYPERION; kinase N-associated protein; LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; protein hyperion; protein kinase A anchoring protein 9; Protein kinase A-anchoring protein 9; protein phosphatase 1, regulatory subunit 45; protein yotiao; YOTIAO
Description (eCommerce)
AKAP9/CG-NAP is a member of the A-kinase anchoring protein family that functions as a molecular scaffold for the subcellular compartmentalization of A- kinase signaling molecules. AKAP9/CG-NAP has been found to be critical to repolarization in the human heart. Defects in AKAP9/CG-NAP result in long QT syndrome type 11, a heart disorder characterized by ventricular arrhythmia and prolonged QT intervals. AKAP9/CG-NAP has been shown to form a multiprotein complex with the I(Ks) potassium channel subunit and play an essential role in its phosphorylation by PKA. AKAP9/CG-NAP is also important to centrosome and microtubule cytoskeletal organization.
Description (Vector)
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3.
Gene ID
10142
Gene Name (eCommerce)
A-kinase anchoring protein 9
Gene Name (Vector)
A-kinase anchoring protein 9
Gene Symbol
AKAP9
HGNC ID
HGNC:379
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
945
Protein Name (eCommerce)
A-kinase anchor protein 9
RefSeq ID
NM_005751
RefSeq Synonyms
NM_147185, NM_005751, BC015533,
Research Areas
Cell Cycle,Cytoskeleton,Golgi Apparatus,Kinase/Phosphatase,Neurobiology,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,neurobiology,signal_transduction
Species
human
Target Sentence
AKAP9/CG-NAP is a member of the A-kinase anchoring protein family that functions as a molecular scaffold for the subcellular compartmentalization of A- kinase signaling molecules. AKAP9/CG-NAP has been found to be critical to repolarization in the human heart. Defects in AKAP9/CG-NAP result in long QT syndrome type 11, a heart disorder characterized by ventricular arrhythmia and prolonged QT intervals. AKAP9/CG-NAP has been shown to form a multiprotein complex with the I(Ks) potassium channel subunit and play an essential role in its phosphorylation by PKA. AKAP9/CG-NAP is also important to centrosome and microtubule cytoskeletal organization.
UniProt ID (eCommerce)
Q99996

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.