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human ATP6V0E1 Over-expression AAV

Name 
AAV-h-ATP6V0E1
Cat No 
AAV-201754
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ATP6V0E1.

AAV-201754
AAV-h-ATP6V0E1

Ready-to-use AAV expressing Human ATP6V0E1 (ATPase H+ transporting V0 subunit e1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ATP6H; ATP6V0E; M9.2; Vma21; Vma21p
Description (Vector)
ATP6V0E1 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3.
Gene ID
8992
Gene Name (Vector)
ATPase H+ transporting V0 subunit e1
Gene Symbol
ATP6V0E1
HGNC ID
HGNC:863
ORF Size (aa)
246
ORF Size (bp)
246 bp
RefSeq ID
NM_003945
RefSeq Synonyms
NM_003945, BC119715, BC119714,
Species
human
UniGene ID
Hs.484188

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.