human INS Adenovirus

Name
Ad-h-INS

Cat No
ADV-229744

Availability
4-5 weeks

Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human INS.

ADV-229744

Ad-h-INS

Ready-to-use Adenovirus expressing Human INS (insulin). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

IDDM; IDDM1; IDDM2; ILPR; IRDN; MODY10

Description (Vector)

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

Gene ID

3630

Gene Name (Vector)

insulin

Gene Symbol

INS

HGNC ID

HGNC:6081

ORF Size (aa)

333

ORF Size (bp)

333 bp

RefSeq ID

NM_000207

RefSeq Synonyms

NM_001291897, NM_001185098, NM_001185097, NM_000207, BC005255,

Species

human

UniGene ID

Hs.

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.