human YTHDF2 Adenovirus

Name 
Ad-h-YTHDF2
Cat No 
ADV-227999
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human MCAT.

ADV-227999
Ad-h-YTHDF2

Ready-to-use Adenovirus expressing Human YTHDF2 (YTH N6-methyladenosine RNA binding protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
9430020E02Rik;CAHL;CLL-associated antigen KW-14;HGRG8;high-glucose-regulated protein 8;NY-REN-2;renal carcinoma antigen NY-REN-2;YTH domain family, member 2;YTH domain-containing family protein 2;YTH N(6)-methyladenosine RNA binding protein 2
Description (eCommerce)
YTHDF2 is a member of the YTH-domain containing (YT521-B homology) superfamily which also contains YTHDF1 and YTHDF3. These proteins share a conserved C-terminal YTH domain that specifically interacts with N6-methyladenosine (m6A) modified RNA. The m6A modification is present at internal sites of mRNAs and some non-coding RNAs and plays an important role in mRNA splicing, processing, and stability. YTHDF2 binding appears to promote mRNA degradation, but has minimal effect on translation efficiency. [adapted from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y5A9].
Description (Vector)
YTHDF2 encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosme 21 has been observed in patients with acute myeloid leukemia. YTHDF2 was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Gene ID
51441
Gene Name (eCommerce)
YTH N6-methyladenosine RNA binding protein 2
Gene Name (Vector)
YTH N6-methyladenosine RNA binding protein 2
Gene Symbol
YTHDF2
HGNC ID
HGNC:31675
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1740
ORF Size (bp)
1740 bp
Protein Name (eCommerce)
YTH domain-containing family protein 2
RefSeq ID
NM_016258
RefSeq Synonyms
NM_016258, NM_001173128, NM_001172828, BC002559,
Research Areas
Immunology,RNA Binding
Research Areas (Faceted)
immunology
Species
human
Target Sentence
YTHDF2 is a member of the YTH-domain containing (YT521-B homology) superfamily which also contains YTHDF1 and YTHDF3. These proteins share a conserved C-terminal YTH domain that specifically interacts with N6-methyladenosine (m6A) modified RNA. The m6A modification is present at internal sites of mRNAs and some non-coding RNAs and plays an important role in mRNA splicing, processing, and stability. YTHDF2 binding appears to promote mRNA degradation, but has minimal effect on translation efficiency. [adapted from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y5A9].
UniGene ID
Hs.532286
UniProt ID (eCommerce)
Q9Y5A9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.