human XPA Adenovirus
This is an Adenovirus expressing Human XPA.
ADV-227905
Ad-h-XPA
Ready-to-use Adenovirus expressing Human XPA (XPA, DNA damage recognition and repair factor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DNA repair protein complementing XP-A cells; xeroderma pigmentosum group A-complementing protein; xeroderma pigmentosum, complementation group A; XP1; XPAC
Description (eCommerce)
Mutations in XPA (xeroderma pigmentosum group A-complementing protein) are the cause of xeroderma pigmentosum A (XP-A), an autosomal recessive disease that is mainly characterized by a susceptibility to UV-induced skin cancer and in some cases neurological abnormalities. XPA is one of seven XP complementation groups that have been identified. The XP complementation groups represent genes critical to the nucleotide excision repair (NER) pathway. XPA is thought to function in the recognition of DNA damage and as a processivity factor for XPF and XPG.
Description (Vector)
XPA encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene.
Gene ID
7507
Gene Name (eCommerce)
XPA, DNA damage recognition and repair factor
Gene Name (Vector)
XPA, DNA damage recognition and repair factor
Gene Symbol
XPA
HGNC ID
HGNC:12814
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
822
Protein Name (eCommerce)
DNA repair protein complementing XP-A cells
RefSeq ID
NM_000380
RefSeq Synonyms
NM_000380, BC014965,
Research Areas
Apoptosis,DNA Damage/Repair,Zinc-finger
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Mutations in XPA (xeroderma pigmentosum group A-complementing protein) are the cause of xeroderma pigmentosum A (XP-A), an autosomal recessive disease that is mainly characterized by a susceptibility to UV-induced skin cancer and in some cases neurological abnormalities. XPA is one of seven XP complementation groups that have been identified. The XP complementation groups represent genes critical to the nucleotide excision repair (NER) pathway. XPA is thought to function in the recognition of DNA damage and as a processivity factor for XPF and XPG.
UniGene ID
Hs.654364
UniProt ID (eCommerce)
P23025
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.