human WWP2 Adenovirus
This is an Adenovirus expressing Human WWP2.
ADV-227859
Ad-h-WWP2
Ready-to-use Adenovirus expressing Human WWP2 (WW domain containing E3 ubiquitin protein ligase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AIP2; atrophin-1 interacting protein 2; Atrophin-1-interacting protein 2; HECT-type E3 ubiquitin transferase WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2; WW domain-containing protein 2; WWp2-like
Description (eCommerce)
WWP2 (WW domain containing E3 ubiquitin protein ligase 2) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. WWP2 has been shown to polyubiquitinate POU5F1 by 'Lys-63'-linked conjugation and promote its proteasomal degradation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O00308].
Description (Vector)
WWP2 encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10.
Gene ID
11060
Gene Name (eCommerce)
WW domain containing E3 ubiquitin protein ligase 2
Gene Name (Vector)
WW domain containing E3 ubiquitin protein ligase 2
Gene Symbol
WWP2
HGNC ID
HGNC:16804
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2613
ORF Size (bp)
2613 bp
Protein Name (eCommerce)
NEDD4-like E3 ubiquitin-protein ligase WWP2
RefSeq ID
NM_007014
RefSeq Synonyms
NM_199424, NM_199423, NM_007014, NM_001270455, NM_001270454, NM_001270453, BC064531, BC013645, BC000108,
Research Areas
Gene Expression,Host-Virus Interactions,RNA Binding,Transcription Factor/Regulator,Ubiquitination
Research Areas (Faceted)
cell_biology,infectious_disease,transcription_translation
Species
human
Target Sentence
WWP2 (WW domain containing E3 ubiquitin protein ligase 2) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. WWP2 has been shown to polyubiquitinate POU5F1 by 'Lys-63'-linked conjugation and promote its proteasomal degradation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O00308].
UniGene ID
Hs.408458
UniProt ID (eCommerce)
O00308
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.