human WAS Adenovirus

Name 
Ad-h-WAS
Cat No 
ADV-227596
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human WAS.

ADV-227596
Ad-h-WAS

Ready-to-use Adenovirus expressing Human WAS (Wiskott-Aldrich syndrome). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
eczema-thrombocytopenia; IMD2; SCNX; THC; THC1; thrombocytopenia 1 (X-linked); WASP; WASPA; wiskott-Aldrich syndrome protein
Description (eCommerce)
Wiskott-Aldrich syndrome protein WASP is part of the WAS family of proteins that mediate cell signals that regulate the dynamics of the actin cytoskeleton. WASP associates with Cdc42, a Rho-family GTPase, and the cytoskeletal organizing complex, Arp2/3, to stimulate actin-polymerization. WASP also binds with RAC, NCK, FYN, SRC kinase FGR, BTK, ABL, PSTPIP1, WIP, and to the p85 subunit of PLC-gamma.
Description (Vector)
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.
Gene ID
7454
Gene Name (eCommerce)
Wiskott-Aldrich syndrome
Gene Name (Vector)
Wiskott-Aldrich syndrome
Gene Symbol
WAS
HGNC ID
HGNC:12731
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1509
ORF Size (bp)
1509 bp
Protein Name (eCommerce)
Wiskott-Aldrich syndrome protein
RefSeq ID
NM_000377
RefSeq Synonyms
NM_000377, BC012738,
Research Areas
Angiogenesis,Cytoskeleton,Immunology,Innate Immunity,Phospho-specific,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,Transport
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
Wiskott-Aldrich syndrome protein WASP is part of the WAS family of proteins that mediate cell signals that regulate the dynamics of the actin cytoskeleton. WASP associates with Cdc42, a Rho-family GTPase, and the cytoskeletal organizing complex, Arp2/3, to stimulate actin-polymerization. WASP also binds with RAC, NCK, FYN, SRC kinase FGR, BTK, ABL, PSTPIP1, WIP, and to the p85 subunit of PLC-gamma.
UniGene ID
Hs.2157
UniProt ID (eCommerce)
P42768

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.