human VHL Adenovirus
This is an Adenovirus expressing Human VHL.
ADV-227474
Ad-h-VHL
Ready-to-use Adenovirus expressing Human VHL (von Hippel-Lindau tumor suppressor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HRCA1; pVHL; RCA1; VHL1
Description (Vector)
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Gene ID
7428
Gene Name (Vector)
von Hippel-Lindau tumor suppressor
Gene Symbol
VHL
HGNC ID
HGNC:12687
ORF Size (aa)
519
RefSeq ID
NM_000551
RefSeq Synonyms
NM_198156, NM_000551, BC058831,
Species
human
UniGene ID
Hs.517792
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.