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human PCLAF Adenovirus

Name 
Ad-h-PCLAF
Cat No 
ADV-227218
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PCLAF.

ADV-227218
Ad-h-PCLAF

Ready-to-use Adenovirus expressing Human PCLAF (PCNA clamp associated factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
HCV NS5A-transactivated protein 9; hepatitis C virus NS5A-transactivated protein 9; KIAA0101; L5; NS5ATP9; OEATC; OEATC1; OEATC-1; of 15 kDa; overexpressed in anaplastic thyroid carcinoma 1; p15(PAF); p15/PAF; p15PAF; PAF; PAF15; PCNA-associated factor; PCNA-associated factor of 15 kDa; PCNA-clamp-associated factor
Description (eCommerce)
PCNA associated factor (PAF) is a PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15004].
Gene ID
9768
Gene Name (eCommerce)
PCNA clamp associated factor
Gene Name (Vector)
PCNA clamp associated factor
Gene Symbol
PCLAF
HGNC ID
HGNC:28961
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
336
ORF Size (bp)
336 bp
Protein Name (eCommerce)
PCNA-associated factor
RefSeq ID
NM_014736
RefSeq Synonyms
NM_014736, NM_001029989, BC016782, BC007101, BC005832,
Research Areas
Cell Biology,Cell Cycle,Cytoskeleton,DNA Damage/Repair,DNA Replication,Replication,Ubiquitination
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
PCNA associated factor (PAF) is a PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15004].
UniGene ID
Hs.81892
UniProt ID (eCommerce)
Q15004

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.