human UMOD Adenovirus
This is an Adenovirus expressing Human UMOD.
ADV-227176
Ad-h-UMOD
Ready-to-use Adenovirus expressing Human UMOD (uromodulin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ADMCKD2; FJHN; HNFJ; HNFJ1; MCKD2; THGP; THP
Description (Vector)
UMOD encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
Gene ID
7369
Gene Name (Vector)
uromodulin
Gene Symbol
UMOD
HGNC ID
HGNC:12559
ORF Size (aa)
1836
ORF Size (bp)
1836 bp
RefSeq ID
NM_003361
RefSeq Synonyms
NM_003361, NM_001278614, NM_001008389, BC035975,
Species
human
UniGene ID
Hs.654425
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.