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human UBTF Adenovirus

Name 
Ad-h-UBTF
Cat No 
ADV-227085
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human UBTF.

ADV-227085
Ad-h-UBTF

Ready-to-use Adenovirus expressing Human UBTF (upstream binding transcription factor, RNA polymerase I). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
90-kDa nucleolus organizer region autoantigen; autoantigen NOR-90; CONDBA; NOR-90; nucleolar transcription factor 1; UBF; UBF1; UBF-1; UBF2; upstream binding transcription factor, RNA polymerase I; Upstream-binding factor 1
Description (eCommerce)
Upstream binding factor (UBF) was originally identified as a multi-HMG (high mobility group)-box DNA binding domain protein that could enhance the in vitro assembly of the RNA polymerase I initiation complex. UBF is a transcription factor that recognizes the ribosomal RNA gene promoter required for the expression of 18S, 5.8S, and 28S ribosomal RNAs.
Description (Vector)
UBTF encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11.
Gene ID
7343
Gene Name (eCommerce)
upstream binding transcription factor
Gene Name (Vector)
upstream binding transcription factor, RNA polymerase I
Gene Symbol
UBTF
HGNC ID
HGNC:12511
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2184
ORF Size (bp)
2184 bp
Protein Name (eCommerce)
Nucleolar transcription factor 1
RefSeq ID
NM_014233
RefSeq Synonyms
NM_014233, NM_001076684, NM_001076683, BC042297,
Research Areas
Epigenetic Regulation of Gene Expression,Gene Expression,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Upstream binding factor (UBF) was originally identified as a multi-HMG (high mobility group)-box DNA binding domain protein that could enhance the in vitro assembly of the RNA polymerase I initiation complex. UBF is a transcription factor that recognizes the ribosomal RNA gene promoter required for the expression of 18S, 5.8S, and 28S ribosomal RNAs.
UniGene ID
Hs.89781
UniProt ID (eCommerce)
P17480

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.