human ARRB1 Over-expression AAV

Name 
AAV-h-ARRB1
Cat No 
AAV-201475
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ARRB1.

AAV-201475
AAV-h-ARRB1

Ready-to-use AAV expressing Human ARRB1 (arrestin beta 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ARB1; ARR1; arrestin 2; Arrestin beta-1; beta-arrestin-1; non-visual arrestin-2
Description (eCommerce)
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Beta-arrestin 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions [taken from NCBI Entrez Gene (Gene ID: 408)].
Gene ID
408
Gene Name (eCommerce)
arrestin beta 1
Gene Name (Vector)
arrestin beta 1
Gene Symbol
ARRB1
HGNC ID
HGNC:711
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1257
ORF Size (bp)
1257 bp
Protein Name (eCommerce)
Beta-arrestin-1
RefSeq ID
NM_004041
RefSeq Synonyms
NM_020251, NM_004041, BC003636,
Research Areas
Cancer,Cardiology,Cardiovascular,Golgi Apparatus,Histone Modification,Interleukin Signaling,Kinase/Phosphatase,MAPK Signaling,Neurobiology,Notch Signaling,Rho Signaling,Signal Transduction,Transcription Factor/Regulator,Ubiquitination,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Beta-arrestin 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions [taken from NCBI Entrez Gene (Gene ID: 408)].
UniGene ID
Hs.625320
UniProt ID (eCommerce)
P49407

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.