human ARPC4 Over-expression AAV

Name 
AAV-h-ARPC4
Cat No 
AAV-201466
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ARPC4.

AAV-201466
AAV-h-ARPC4

Ready-to-use AAV expressing Human ARPC4 (actin related protein 2/3 complex subunit 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
actin related protein 2/3 complex, subunit 4, 20kDa; actin-related protein 2/3 complex subunit 4; ARC20; arp2/3 complex 20 kDa subunit; arp2/3 protein complex subunit p20; P20-ARC
Description (eCommerce)
Actin-related protein 2/3 complex subunit 4 (ARPC4) functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. ARPC4 seems to contact the mother actin filament [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P59998].
Description (Vector)
ARPC4 encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. ARPC4 encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein.
Gene ID
10093
Gene Name (eCommerce)
actin related protein 2/3 complex subunit 4
Gene Name (Vector)
actin related protein 2/3 complex subunit 4
Gene Symbol
ARPC4
HGNC ID
HGNC:707
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
504
ORF Size (bp)
504 bp
Protein Name (eCommerce)
Actin-related protein 2/3 complex subunit 4
RefSeq ID
NM_005718
RefSeq Synonyms
NM_005718, NM_001198780, NM_001024960, NM_001024959, BC152790, BC065423,
Research Areas
Cytoskeleton,Immunology,Innate Immunity,PDGF Signaling,RAC1 Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
Actin-related protein 2/3 complex subunit 4 (ARPC4) functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. ARPC4 seems to contact the mother actin filament [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P59998].
UniGene ID
Hs.323342
UniProt ID (eCommerce)
P59998

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.