human TNNI1 Adenovirus
This is an Adenovirus expressing Human TNNI1.
ADV-226129
Ad-h-TNNI1
Ready-to-use Adenovirus expressing Human TNNI1 (troponin I1, slow skeletal type). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SSTNI; TNN1
Description (Vector)
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.
Gene ID
7135
Gene Name (Vector)
troponin I1, slow skeletal type
Gene Symbol
TNNI1
HGNC ID
HGNC:11945
ORF Size (aa)
564
RefSeq ID
NM_003281
RefSeq Synonyms
NM_003281, BC012601, BC012600,
Species
human
UniGene ID
Hs.320890
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.