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human TNFSF9 Adenovirus

Name 
Ad-h-TNFSF9
Cat No 
ADV-226115
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human TNFSF9.

ADV-226115
Ad-h-TNFSF9

Ready-to-use Adenovirus expressing Human TNFSF9 (tumor necrosis factor superfamily member 9). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
4-1BB ligand; 4-1BBL; 4-1BB-L; CD137L; homolog of mouse 4-1BB-L; receptor 4-1BB ligand; TNLG5A; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5A; tumor necrosis factor ligand superfamily member 9; tumor necrosis factor superfamily member 9
Description (eCommerce)
4-1BBL (aka CD137L or TNFSF9) is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. 4-1BBL and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells; they are also involved in promoting T lymphocyte proliferation. 4-1BBL has been shown to be required for the optimal CD8 responses in CD8 T cells. 4-1BBL is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. [taken from NCBI Entrez Gene (Gene ID: 8744)].
Description (Vector)
TNFSF9 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Gene ID
8744
Gene Name (eCommerce)
TNF superfamily member 9
Gene Name (Vector)
tumor necrosis factor superfamily member 9
Gene Symbol
TNFSF9
HGNC ID
HGNC:11939
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
765
Protein Name (eCommerce)
Tumor necrosis factor ligand superfamily member 9
RefSeq ID
NM_003811
RefSeq Synonyms
NM_003811, BC104807, BC104805,
Research Areas
Apoptosis,Cancer,Immunology,Signal Transduction
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,immunology
Species
human
Target Sentence
4-1BBL (aka CD137L or TNFSF9) is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. 4-1BBL and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells; they are also involved in promoting T lymphocyte proliferation. 4-1BBL has been shown to be required for the optimal CD8 responses in CD8 T cells. 4-1BBL is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. [taken from NCBI Entrez Gene (Gene ID: 8744)].
UniGene ID
Hs.1524
UniProt ID (eCommerce)
P41273

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.