human ARHGEF2 Over-expression AAV

Name
AAV-h-ARHGEF2

Cat No
AAV-201363

Availability
4-5 weeks

This is an AAV expressing Human ARHGEF2.

AAV-201363

AAV-h-ARHGEF2

Ready-to-use AAV expressing Human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GEF; GEFH1; GEF-H1; guanine nucleotide exchange factor H1; LFP40; microtubule-regulated Rho-GEF; NEDMHM; P40; proliferating cell nucleolar antigen p40; rho guanine nucleotide exchange factor 2; Rho/Rac guanine nucleotide exchange factor (GEF) 2

Description (eCommerce)

GEF-H1 (guanine nucleotide exchange factor H1) is a microtubule regulated guanine nucleotide exchange factor for the RhoA GTPase. It catalyzes the exchange of GDP for GTP by Rho in response to microtubule destabilization. GEF-H1 has shown to be regulated during cytokinesis and plays a role in the cleavage furrow.

Description (Vector)

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID

9181

Gene Name (eCommerce)

Rho/Rac guanine nucleotide exchange factor 2

Gene Name (Vector)

Rho/Rac guanine nucleotide exchange factor 2

Gene Symbol

ARHGEF2

HGNC ID

HGNC:682

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2880

ORF Size (bp)

2880 bp

Protein Name (eCommerce)

Rho guanine nucleotide exchange factor 2

RefSeq ID

NM_004723

RefSeq Synonyms

NM_004723, NM_001162384, NM_001162383, BC020567,

Research Areas

Apoptosis,Cell Cycle,Cell Division,Cytoskeleton,Golgi Apparatus,GPCR Signaling,Immunology,Innate Immunity,Neurobiology,Neurodevelopment,Neurogenesis,NGF Signaling,Rho Signaling,Signal Transduction,T-cell Receptor Signaling,Zinc-finger

Research Areas (Faceted)

cell_biology,cell_cycle,developmental_biology,genetics,immunology,neurobiology,signal_transduction

Species

human

Target Sentence

UniGene ID

Hs.655209

UniProt ID (eCommerce)

Q92974

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.