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human TBL1XR1 Adenovirus

Name 
Ad-h-TBL1XR1
Cat No 
ADV-225131
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human TBL1XR1.

ADV-225131
Ad-h-TBL1XR1

Ready-to-use Adenovirus expressing Human TBL1XR1 (transducin beta like 1 X-linked receptor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C21; DC42; F-box-like/WD repeat-containing protein TBL1XR1; IRA1; MRD41; nuclear receptor co-repressor/HDAC3 complex subunit; nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; TBLR1; Transducin beta-like 1X-related protein 1
Description (eCommerce)
TBLR1 is a six WD-40 repeat protein with high sequence homology to TBL1 (transducin beta-like protein 1) and is part of the SMRT (silencing mediator of retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor) complexes that interact with nuclear receptors and repress transcription. Biochemical characterization of SMRT and N-CoR complexes demonstrate that SMRT and N-CoR are present in complexes that include HDAC3 (histone deacetylase 3), TBL1, and TBLR1. Association with HDAC3 indicates that these complexes may repress transcription through histone deacetylation and chromatin remodeling.
Description (Vector)
TBL1XR1 has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation.
Gene ID
79718
Gene Name (eCommerce)
transducin beta like 1 X-linked receptor 1
Gene Name (Vector)
transducin beta like 1 X-linked receptor 1
Gene Symbol
TBL1XR1
HGNC ID
HGNC:29529
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1545
ORF Size (bp)
1545 bp
Protein Name (eCommerce)
F-box-like/WD repeat-containing protein TBL1XR1
RefSeq ID
NM_024665
RefSeq Synonyms
NM_024665, NM_001321195, NM_001321194, NM_001321193, BC113421,
Research Areas
Cancer,Cell Cycle,Chromatin Remodeling,Metabolism/Metabolic Process,Notch Signaling,Signal Transduction,Transcription Factor/Regulator,Ubiquitination,Wnt Signaling
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,transcription_translation,metabolism,signal_transduction,developmental_biology,genetics,transcription_translation,signal_transduction,developmental_biology
Species
human
Target Sentence
TBLR1 is a six WD-40 repeat protein with high sequence homology to TBL1 (transducin beta-like protein 1) and is part of the SMRT (silencing mediator of retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor) complexes that interact with nuclear receptors and repress transcription. Biochemical characterization of SMRT and N-CoR complexes demonstrate that SMRT and N-CoR are present in complexes that include HDAC3 (histone deacetylase 3), TBL1, and TBLR1. Association with HDAC3 indicates that these complexes may repress transcription through histone deacetylation and chromatin remodeling.
UniGene ID
Hs.715537
UniProt ID (eCommerce)
Q9BZK7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.