human ARAP1 Over-expression AAV

Name
AAV-h-ARAP1

Cat No
AAV-201252

Availability
4-5 weeks

This is an AAV expressing Human ARAP1.

AAV-201252

AAV-h-ARAP1

Ready-to-use AAV expressing Human ARAP1 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1; centaurin-delta-2; CENTD2; cnt-d2

Description (eCommerce)

CENTD2/ARAP1 is an adapter protein that functions as an Arf 1 and Rho GTPase-activation protein. CENTD2/ARAP1 associates with the Golgi and appears to play a role in cytoskeleton remodeling as well as membrane receptor recycling and trafficking.

Description (Vector)

ARAP1 contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

116985

Gene Name (eCommerce)

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

Gene Name (Vector)

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

Gene Symbol

ARAP1

HGNC ID

HGNC:16925

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3402

ORF Size (bp)

3402 bp

Protein Name (eCommerce)

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

RefSeq ID

NM_015242

RefSeq Synonyms

NM_015242, NM_001135190, NM_001040118, BC144562, BC140792,

Research Areas

Cytoskeleton,EGFR Signaling,Golgi Apparatus,Immunology,PDGF Signaling,RAC1 Signaling,Rho Signaling,Signal Transduction,T-cell Receptor Signaling,Zinc-finger

Research Areas (Faceted)

cell_biology,immunology,signal_transduction

Species

human

Target Sentence

UniGene ID

Hs.503165

UniProt ID (eCommerce)

Q96P48

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.