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human STAT6 Adenovirus

Name 
Ad-h-STAT6
Cat No 
ADV-224543
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human STAT6.

ADV-224543
Ad-h-STAT6

Ready-to-use Adenovirus expressing Human STAT6 (signal transducer and activator of transcription 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
D12S1644; IL-4 Stat; IL-4-STAT; signal transducer and activator of transcription 6; signal transducer and activator of transcription 6, interleukin-4 induced; STAT, interleukin4-induced; STAT6B; STAT6C; transcription factor IL-4 STAT
Description (eCommerce)
STAT6 is part of the STAT (signal transducers and activators of transcription) family of transcription factors that relays signals from cytokine receptors to the nucleus where they act as transcriptional activators. STAT6 mediates signals that originate from the IL-4 receptor via JAKs (Janus Kinases) and activates a gene program involved in B- and T- cell differentiation, proliferation, and apoptosis.
Description (Vector)
STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
Gene ID
6778
Gene Name (eCommerce)
signal transducer and activator of transcription 6
Gene Name (Vector)
signal transducer and activator of transcription 6
Gene Symbol
STAT6
HGNC ID
HGNC:11368
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2544
ORF Size (bp)
2544 bp
Protein Name (eCommerce)
Signal transducer and activator of transcription 6
RefSeq ID
NM_003153
RefSeq Synonyms
NM_003153, NM_001178081, NM_001178080, NM_001178079, NM_001178078, BC075852,
Research Areas
Cancer,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,PDGF Signaling,Signal Transduction,Transcription Factor/Regulator,Transport,TSLP Signaling
Research Areas (Faceted)
cancer,cell_biology,immunology,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
STAT6 is part of the STAT (signal transducers and activators of transcription) family of transcription factors that relays signals from cytokine receptors to the nucleus where they act as transcriptional activators. STAT6 mediates signals that originate from the IL-4 receptor via JAKs (Janus Kinases) and activates a gene program involved in B- and T- cell differentiation, proliferation, and apoptosis.
UniGene ID
Hs.524518
UniProt ID (eCommerce)
P42226

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.