human APTX Over-expression AAV

Name 
AAV-h-APTX
Cat No 
AAV-201226
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human APTX.

AAV-201226
AAV-h-APTX

Ready-to-use AAV expressing Human APTX (aprataxin). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AOA; AOA1; aprataxin; AXA1; EAOH; EOAHA; FHA-HIT; forkhead-associated domain histidine triad-like protein
Description (eCommerce)
The Aprataxin gene was identified by linkage analysis as the defective gene in the neurogenerative disorder ataxia with oculomotor apraxia type 1 (AOA1) which is characterized by cerebellar ataxia, peripheral neuropathy, and hypoalbuminemia. Aprataxin functions in the DNA damage response and is involved in single-strand and double-strand break repair, and base excision repair.
Description (Vector)
APTX encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene.
Gene ID
54840
Gene Name (eCommerce)
aprataxin
Gene Name (Vector)
aprataxin
Gene Symbol
APTX
HGNC ID
HGNC:15984
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
765
ORF Size (bp)
765 bp
Protein Name (eCommerce)
Aprataxin
RefSeq ID
NM_001195254
RefSeq Synonyms
NM_175073, NM_175069, NM_001195254, NM_001195252, NM_001195251, NM_001195250, NM_001195249, NM_001195248, BC104881, BC032650, BC001628,
Research Areas
Apoptosis,DNA Damage/Repair,Neurobiology,Neurodegeneration,RNA Binding,Zinc-finger
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,neurobiology,genetics,cell_biology
Species
human
Target Sentence
The Aprataxin gene was identified by linkage analysis as the defective gene in the neurogenerative disorder ataxia with oculomotor apraxia type 1 (AOA1) which is characterized by cerebellar ataxia, peripheral neuropathy, and hypoalbuminemia. Aprataxin functions in the DNA damage response and is involved in single-strand and double-strand break repair, and base excision repair.
UniGene ID
Hs.20158
UniProt ID (eCommerce)
Q7Z2E3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.