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human SSH1 Adenovirus

Name 
Ad-h-SSH1
Cat No 
ADV-224391
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human SSH1.

ADV-224391
Ad-h-SSH1

Ready-to-use Adenovirus expressing Human SSH1 (slingshot protein phosphatase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
hSSH-1L; protein phosphatase Slingshot homolog 1; slingshot homolog 1; SSH1L; SSH-1L; SSH-like protein 1
Description (eCommerce)
SSH1, also known as slingshot, is a phosphatase that functions to activate the actin severing protein, ADF/cofilin, and influence actin dynamics. There are three members of the slingshot family, SSH1, SSH2, and SSH3. SSH1 has been shown to function downstream of alpha6beta4 integrin/Rac1 signaling in conjunction with 14-3-3 association.
Description (Vector)
SSH1 belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
54434
Gene Name (eCommerce)
slingshot protein phosphatase 1
Gene Name (Vector)
slingshot protein phosphatase 1
Gene Symbol
SSH1
HGNC ID
HGNC:30579
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3150
ORF Size (bp)
3150 bp
Protein Name (eCommerce)
Protein phosphatase Slingshot homolog 1
RefSeq ID
NM_018984
RefSeq Synonyms
NM_018984, NM_001161331, NM_001161330, BC062341,
Research Areas
Axonogenesis,Cytoskeleton,FGF Signaling,Kinase/Phosphatase,Neurobiology,Phosphatase,Signal Transduction
Research Areas (Faceted)
signal_transduction,neurobiology,developmental_biology,cell_biology,signal_transduction,developmental_biology,cell_biology,neurobiology
Species
human
Target Sentence
SSH1, also known as slingshot, is a phosphatase that functions to activate the actin severing protein, ADF/cofilin, and influence actin dynamics. There are three members of the slingshot family, SSH1, SSH2, and SSH3. SSH1 has been shown to function downstream of alpha6beta4 integrin/Rac1 signaling in conjunction with 14-3-3 association.
UniGene ID
Hs.199763
UniProt ID (eCommerce)
Q8WYL5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.