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human SIGLEC12 Adenovirus

Name 
Ad-h-SIGLEC12
Cat No 
ADV-222990
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human SIGLEC12.

ADV-222990
Ad-h-SIGLEC12

Ready-to-use Adenovirus expressing Human SIGLEC12 (sialic acid binding Ig like lectin 12 (gene/pseudogene)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
S2V; Siglec-XII; SIGLECL1; SLG
Description (Vector)
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.
Gene ID
89858
Gene Name (Vector)
sialic acid binding Ig like lectin 12 (gene/pseudogene)
Gene Symbol
SIGLEC12
HGNC ID
HGNC:15482
ORF Size (aa)
1788
ORF Size (bp)
1788 bp
RefSeq ID
NM_053003
RefSeq Synonyms
NM_053003, NM_033329, BC035809,
Species
human
UniGene ID
Hs.249741

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.