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human SH3BP2 Adenovirus

Name 
Ad-h-SH3BP2
Cat No 
ADV-222898
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human SH3BP2.

ADV-222898
Ad-h-SH3BP2

Ready-to-use Adenovirus expressing Human SH3BP2 (SH3 domain binding protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
3BP2; 3BP-2; Abl-SH3 binding protein 2; CRBM; CRPM; epididymis secretory sperm binding protein; RES4-23; SH3 domain-binding protein 2; TNFAIP3 interacting protein 2
Description (eCommerce)
SH3 domain-binding protein 2 (SH3BP2) N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases, and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism, an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws followed by development of fibrous tissue masses and characteristic facial swelling [taken from NCBI Entrez Gene (Gene ID: 6452)].
Description (Vector)
SH3BP2 has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
6452
Gene Name (eCommerce)
SH3 domain binding protein 2
Gene Name (Vector)
SH3 domain binding protein 2
Gene Symbol
SH3BP2
HGNC ID
HGNC:10825
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1686
ORF Size (bp)
1686 bp
Protein Name (eCommerce)
SH3 domain-binding protein 2
RefSeq ID
NM_003023
RefSeq Synonyms
NM_003023, NM_001145856, NM_001145855, NM_001122681, BC022996,
Research Areas
B-cell Receptor Signaling,Immunology,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
signal_transduction,immunology
Species
human
Target Sentence
SH3 domain-binding protein 2 (SH3BP2) N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases, and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism, an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws followed by development of fibrous tissue masses and characteristic facial swelling [taken from NCBI Entrez Gene (Gene ID: 6452)].
UniGene ID
Hs.167679
UniProt ID (eCommerce)
P78314

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.