human RPA1 Adenovirus
This is an Adenovirus expressing Human RPA1.
ADV-221531
Ad-h-RPA1
Ready-to-use Adenovirus expressing Human RPA1 (replication protein A1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HSSB; MST075; MSTP075; REPA1; replication factor A protein 1; replication protein A 70 kDa DNA-binding subunit; replication protein A1, 70kDa; RF-A; RF-A protein 1; RP-A; RP-A p70; RPA70; single-stranded DNA-binding protein
Description (eCommerce)
Replication protein A (RPA) is a multisubunit complex that carries out DNA mismatch repair (MMR) in association with MSH2 (a subunit of human MutS heterodimers), MLH1 (a subunit of human MutL heterodimers), PCNA, and DNA polymerase-delta. RPA is composed of a heterotrimer that includes subunits of 70 kDa (RPA1), 32kDa (RPA2), and 14kDa (RPA3). RPA1, the 70 kDa subunit, is an ssDNA binding protein that has been shown to be phosphorylated by ATM and ATR in response to DNA damage. In addition to a role in MMR, RPA also functions in the initiation of DNA replication and DNA unwinding at origins of replication.
Gene ID
6117
Gene Name (eCommerce)
replication protein A1
Gene Name (Vector)
replication protein A1
Gene Symbol
RPA1
HGNC ID
HGNC:10289
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1851
ORF Size (bp)
1851 bp
Protein Name (eCommerce)
Replication protein A 70 kDa DNA-binding subunit
RefSeq ID
NM_002945
RefSeq Synonyms
NM_002945, BC018126,
Research Areas
Cardiology,Cardiovascular,Cell Cycle,Chromatin Remodeling,Cytoskeleton,DNA Damage/Repair,DNA Replication,Fanconi anemia,Homologous Recombination,Hypoxia,Meiosis,Neurobiology,Replication,Signal Transduction,Telomeric Maintenance,Zinc-finger
Research Areas (Faceted)
cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Replication protein A (RPA) is a multisubunit complex that carries out DNA mismatch repair (MMR) in association with MSH2 (a subunit of human MutS heterodimers), MLH1 (a subunit of human MutL heterodimers), PCNA, and DNA polymerase-delta. RPA is composed of a heterotrimer that includes subunits of 70 kDa (RPA1), 32kDa (RPA2), and 14kDa (RPA3). RPA1, the 70 kDa subunit, is an ssDNA binding protein that has been shown to be phosphorylated by ATM and ATR in response to DNA damage. In addition to a role in MMR, RPA also functions in the initiation of DNA replication and DNA unwinding at origins of replication.
UniGene ID
Hs.461925
UniProt ID (eCommerce)
P27694
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.