human RB1CC1 Adenovirus
This is an Adenovirus expressing Human RB1CC1.
ADV-220821
Ad-h-RB1CC1
Ready-to-use Adenovirus expressing Human RB1CC1 (RB1 inducible coiled-coil 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
200 kDa FAK family kinase-interacting protein; ATG17; CC1; FAK family kinase-interacting protein of 200 kDa; FIP200; phosphatase 1, regulatory subunit 131; PPP1R131; RB1-inducible coiled-coil protein 1
Description (eCommerce)
FIP200 (FAK-family interacting protein of 200 kDa) appears to play several key roles related to cell growth, proliferation, development, and tumorigenesis. FIP200 was originally identified in a yeast two-hybrid screen for Pyk2 kinase interacting proteins. It was later identified as a protein that interacts with FAK (focal adhesion kinase), a signal transducing protein that mediates signals from the extracellular matrix to the cytoskeleton to influence cell motility, and cell cycle progression. FIP200 is also known as RB1CC1 (RB1-inducible coiled-coil 1) and has been found to function as a regulator of the retinoblastoma 1 (RB1) tumor suppressor. FIP200 associates with the tumor suppressor TSC1 which partners with TSC2 to antagonize the mTOR signaling pathway. FIP200 association with TSC2 promotes mTOR activity by interfering with the antagonistic effects of the TSC1-TSC2 complex.
Description (Vector)
RB1CC1 interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene ID
9821
Gene Name (eCommerce)
RB1 inducible coiled-coil 1
Gene Name (Vector)
RB1 inducible coiled-coil 1
Gene Symbol
RB1CC1
HGNC ID
HGNC:15574
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4785
ORF Size (bp)
4785 bp
Protein Name (eCommerce)
RB1-inducible coiled-coil protein 1
RefSeq ID
NM_014781
RefSeq Synonyms
NM_014781, NM_001083617, BC017556,
Research Areas
Apoptosis,Autophagy,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Kinase/Phosphatase,mTOR Signaling,Signal Transduction,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
FIP200 (FAK-family interacting protein of 200 kDa) appears to play several key roles related to cell growth, proliferation, development, and tumorigenesis. FIP200 was originally identified in a yeast two-hybrid screen for Pyk2 kinase interacting proteins. It was later identified as a protein that interacts with FAK (focal adhesion kinase), a signal transducing protein that mediates signals from the extracellular matrix to the cytoskeleton to influence cell motility, and cell cycle progression. FIP200 is also known as RB1CC1 (RB1-inducible coiled-coil 1) and has been found to function as a regulator of the retinoblastoma 1 (RB1) tumor suppressor. FIP200 associates with the tumor suppressor TSC1 which partners with TSC2 to antagonize the mTOR signaling pathway. FIP200 association with TSC2 promotes mTOR activity by interfering with the antagonistic effects of the TSC1-TSC2 complex.
UniGene ID
Hs.196102
UniProt ID (eCommerce)
Q8TDY2
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.