human RANBP1 Adenovirus

Name 
Ad-h-RANBP1
Cat No 
ADV-220700
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human RANBP1.

ADV-220700
Ad-h-RANBP1

Ready-to-use Adenovirus expressing Human RANBP1 (RAN binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
HpaII tiny fragments locus 9A; HTF9A; Ran-binding protein 1; RanBP1; ran-specific GTPase-activating protein; testis secretory sperm-binding protein Li 221n
Description (eCommerce)
Ran-binding protein 1 (RanBP1) binds to the GTP-binding protein, Ran, when it is specifically complexed with GTP. RanBP1 binding to GTP-charged RAN increases the catalytic efficiency of GTP hydrolysis activated by RanGAP, the Ran specific GTPase-activating protein. RanBP1 is also a negative regulator of RCC1 which functions in the nuclear pore transport process and cell cycle progression.
Description (Vector)
Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.
Gene ID
5902
Gene Name (eCommerce)
RAN binding protein 1
Gene Name (Vector)
RAN binding protein 1
Gene Symbol
RANBP1
HGNC ID
HGNC:9847
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
603
Protein Name (eCommerce)
Ran-specific GTPase-activating protein
RefSeq ID
NM_002882
RefSeq Synonyms
NM_002882, NM_001278641, NM_001278640, NM_001278639, BC152785,
Research Areas
Cancer,Cell Cycle,Host-Virus Interactions,Nuclear Import/Export,Signal Transduction,Transport,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,infectious_disease,signal_transduction
Species
human
Target Sentence
Ran-binding protein 1 (RanBP1) binds to the GTP-binding protein, Ran, when it is specifically complexed with GTP. RanBP1 binding to GTP-charged RAN increases the catalytic efficiency of GTP hydrolysis activated by RanGAP, the Ran specific GTPase-activating protein. RanBP1 is also a negative regulator of RCC1 which functions in the nuclear pore transport process and cell cycle progression.
UniGene ID
Hs.24763
UniProt ID (eCommerce)
P43487

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.