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human RAI1 Adenovirus

Name 
Ad-h-RAI1
Cat No 
ADV-220677
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human RAI1.

ADV-220677
Ad-h-RAI1

Ready-to-use Adenovirus expressing Human RAI1 (retinoic acid induced 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
retinoic acid-induced protein 1; SMCR; Smith-Magenis syndrome chromosome region; SMS
Description (eCommerce)
Defects in Retinoic acid-induced protein 1 (RAI1) are a cause of Smith-Magenis syndrome (SMS) [MIM:182290]. SMS is characterized by congenital mental retardation associated with development and growth delays. The RAI1 has also been associated with schizophrenia [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q7Z5J4].
Description (Vector)
RAI1 is located within the Smith-Magenis syndrome region on chromosome 17. It is highly similar to its mouse counterpart and is expressed at high levels mainly in neuronal tissues. The protein encoded by this gene includes a polymorphic polyglutamine tract in the N-terminal domain. Expression of the mouse counterpart in neurons is induced by retinoic acid. RAI1 is associated with both the severity of the phenotype and the response to medication in schizophrenic patients.
Gene ID
10743
Gene Name (eCommerce)
retinoic acid induced 1
Gene Name (Vector)
retinoic acid induced 1
Gene Symbol
RAI1
HGNC ID
HGNC:9834
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2901
ORF Size (bp)
2901 bp
Protein Name (eCommerce)
Retinoic acid-induced protein 1
RefSeq ID
NM_030665
RefSeq Synonyms
NM_030665, BC021209,
Research Areas
Neurobiology,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,neurobiology,transcription_translation
Species
human
Target Sentence
Defects in Retinoic acid-induced protein 1 (RAI1) are a cause of Smith-Magenis syndrome (SMS) [MIM:182290]. SMS is characterized by congenital mental retardation associated with development and growth delays. The RAI1 has also been associated with schizophrenia [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q7Z5J4].
UniGene ID
Hs.655395
UniProt ID (eCommerce)
Q7Z5J4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.