human AMACR Over-expression AAV

Name
AAV-h-AMACR

Cat No
AAV-200832

Availability
4-5 weeks

This is an AAV expressing Human AMACR.

AAV-200832

AAV-h-AMACR

Ready-to-use AAV expressing Human AMACR (alpha-methylacyl-CoA racemase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AMACRD; CBAS4; RACE; RM

Description (Vector)

AMACR encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.

Gene ID

23600

Gene Name (Vector)

alpha-methylacyl-CoA racemase

Gene Symbol

AMACR

HGNC ID

HGNC:451

ORF Size (aa)

597

ORF Size (bp)

597 bp

RefSeq ID

NM_014324

RefSeq Synonyms

NM_203382, NM_014324, NM_001167595, BC009471,

Species

human

UniGene ID

Hs.508343

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.