human PTGIS Adenovirus
This is an Adenovirus expressing Human PTGIS.
ADV-220252
Ad-h-PTGIS
Ready-to-use Adenovirus expressing Human PTGIS (prostaglandin I2 synthase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CYP8; CYP8A1; PGIS; PTGI
Description (Vector)
PTGIS encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.
Gene ID
5740
Gene Name (Vector)
prostaglandin I2 synthase
Gene Symbol
PTGIS
HGNC ID
HGNC:9603
ORF Size (aa)
1503
ORF Size (bp)
1503 bp
RefSeq ID
NM_000961
RefSeq Synonyms
NM_000961, BC101811, BC101809,
Species
human
UniGene ID
Hs.302085
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.