human PMS2 Adenovirus

Name 
Ad-h-PMS2
Cat No 
ADV-219280
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PMS2.

ADV-219280
Ad-h-PMS2

Ready-to-use Adenovirus expressing Human PMS2 (PMS1 homolog 2, mismatch repair system component). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DNA mismatch repair protein PMS2; HNPCC4; mismatch repair endonuclease PMS2; MLH4; PMS1 homolog 2, mismatch repair protein; PMS1 protein homolog 2; PMS2 postmeiotic segregation increased 2; PMS2CL; PMSL2; postmeiotic segregation increased 2 nirs variant 6
Description (eCommerce)
PMS2 is an integral component of the DNA mismatch repair (MMR) system that functions to recognize aberrant structures and signals for the repair of single base mismatches or loops in replicated DNA. PMS2 can heterodimerize with DNA mismatch repair protein MLH1 to form the MutL-alpha heterodimer. [taken from NCBI Entrez Gene (Gene ID: 5395)].
Description (Vector)
PMS2 is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.
Gene ID
5395
Gene Name (eCommerce)
PMS1 homolog 2, mismatch repair system component
Gene Name (Vector)
PMS1 homolog 2, mismatch repair system component
Gene Symbol
PMS2
HGNC ID
HGNC:9122
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2589
ORF Size (bp)
2589 bp
Protein Name (eCommerce)
Mismatch repair endonuclease PMS2
RefSeq ID
NM_000535
RefSeq Synonyms
NM_001322015, NM_001322014, NM_001322013, NM_001322012, NM_001322011, NM_001322010, NM_001322009, NM_001322008, NM_001322007, NM_001322006, NM_001322005, NM_001322004, NM_001322003, NM_000535, BC093921,
Research Areas
Cancer,Cell Cycle,Colorectal Cancer,DNA Damage/Repair,Fanconi anemia,Immunology,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,cell_biology,immunology,cancer,transcription_translation
Species
human
Target Sentence
PMS2 is an integral component of the DNA mismatch repair (MMR) system that functions to recognize aberrant structures and signals for the repair of single base mismatches or loops in replicated DNA. PMS2 can heterodimerize with DNA mismatch repair protein MLH1 to form the MutL-alpha heterodimer. [taken from NCBI Entrez Gene (Gene ID: 5395)].
UniGene ID
Hs.632637
UniProt ID (eCommerce)
P54278

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.