human AKT1S1 Over-expression AAV

Name 
AAV-h-AKT1S1
Cat No 
AAV-200704
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human AKT1S1.

AAV-200704
AAV-h-AKT1S1

Ready-to-use AAV expressing Human AKT1S1 (AKT1 substrate 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
40 kDa proline-rich AKT substrate; AKT1 substrate 1 (proline rich); Lobe; PRAS40; proline-rich AKT1 substrate 1
Description (eCommerce)
AktS1/PRAS40 interacts with raptor as a component of the mammalian target of rapamycin complex 1 (mTORC1). One study suggests that AktS1/PRAS40 may function to regulate mTORC1 kinase activity by inhibiting substrate binding. Another study suggests that AktS1/PRAS40 functions downstream of mTORC1 and upstream from its effectors S6K1, and 4E-BP1.
Description (Vector)
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 (PubMed 12524439)).(supplied by OMIM, Mar 2008)
Gene ID
84335
Gene Name (eCommerce)
AKT1 substrate 1
Gene Name (Vector)
AKT1 substrate 1
Gene Symbol
AKT1S1
HGNC ID
HGNC:28426
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
771
ORF Size (bp)
771 bp
Protein Name (eCommerce)
Proline-rich AKT1 substrate 1
RefSeq ID
NM_032375
RefSeq Synonyms
NM_032375, NM_001278160, NM_001278159, NM_001098633, NM_001098632, BC051844, BC016043, BC015562, BC007416,
Research Areas
Apoptosis,Autophagy,B-cell Receptor Signaling,Cancer,EGFR Signaling,EGFR Signaling in Cancer,Fc Receptor Signaling,FGF Signaling,HGF Signaling,Immunology,Innate Immunity,LKB1 Signaling,Metabolism/Metabolic Process,mTOR Signaling,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,SCF-KIT Signaling,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,immunology,metabolism,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
AktS1/PRAS40 interacts with raptor as a component of the mammalian target of rapamycin complex 1 (mTORC1). One study suggests that AktS1/PRAS40 may function to regulate mTORC1 kinase activity by inhibiting substrate binding. Another study suggests that AktS1/PRAS40 functions downstream of mTORC1 and upstream from its effectors S6K1, and 4E-BP1.
UniGene ID
Hs.515542
UniProt ID (eCommerce)
Q96B36

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.