human PLCG1 Adenovirus

Name 
Ad-h-PLCG1
Cat No 
ADV-219127
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PLCG1.

ADV-219127
Ad-h-PLCG1

Ready-to-use Adenovirus expressing Human PLCG1 (phospholipase C gamma 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; NCKAP3; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1 (formerly subtype 148); phospholipase C-148; Phospholipase C-gamma-1; phospholipase C-II; PLC1; PLC148; PLC-148; PLCgamma1; PLC-gamma-1; PLC-II; triphosphoinositide phosphodiesterase
Description (eCommerce)
PLC-gamma1 catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. Also, PLC-gamma1 has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase [taken from NCBI Entrez Gene (Gene ID: 5335].
Description (Vector)
PLCG1 catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
5335
Gene Name (eCommerce)
phospholipase C gamma 1
Gene Name (Vector)
phospholipase C gamma 1
Gene Symbol
PLCG1
HGNC ID
HGNC:9065
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3873
ORF Size (bp)
3873 bp
Protein Name (eCommerce)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
RefSeq ID
NM_002660
RefSeq Synonyms
NM_182811, NM_002660, BC144136, BC136466,
Research Areas
Angiogenesis,Apoptosis,Axon Guidance,B-cell Receptor Signaling,BDNF Signaling,Breast Cancer,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cytokine Signaling,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,Glioma,HGF Signaling,HIF-1 Signaling,Host-Virus Interactions,Hypoxia,IFN Signaling,Immunology,Innate Immunity,Interleukin Signaling,Leptin Signaling,Lung Cancer,Metabolism/Metabolic Process,MicroRNAs in Cancer,Neurobiology,NF-kB Signaling,NGF Signaling,PDGF Signaling,RANKL-RANK Signaling,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TPO Signaling,TRKA Signaling,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,genetics,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
PLC-gamma1 catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. Also, PLC-gamma1 has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase [taken from NCBI Entrez Gene (Gene ID: 5335].
UniGene ID
Hs.268177
UniProt ID (eCommerce)
P19174

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.