human PIN1 Adenovirus

Name 
Ad-h-PIN1
Cat No 
ADV-218972
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PIN1.

ADV-218972
Ad-h-PIN1

Ready-to-use Adenovirus expressing Human PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DOD; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis-trans isomerase Pin1; PPIase Pin1; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1; rotamase Pin1; UBL5
Description (eCommerce)
Peptidyl-prolyl cis-trans isomerase NIMA-interacting protein 1 (Pin1) is an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Pin1 displays a preference for an acidic residue N-terminal to the isomerized proline bond, catalyzing pSer/Thr-Pro cis/trans isomerizations [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13526].
Description (Vector)
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.
Gene ID
5300
Gene Name (eCommerce)
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Gene Name (Vector)
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Gene Symbol
PIN1
HGNC ID
HGNC:8988
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
492
Protein Name (eCommerce)
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
RefSeq ID
NM_006221
RefSeq Synonyms
NM_006221, BC002899,
Research Areas
Cell Cycle,IFN Signaling,Immunology,Innate Immunity,p53 Signaling,PDGF Signaling,Protein Folding,Signal Transduction,Wnt Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,signal_transduction
Species
human
Target Sentence
Peptidyl-prolyl cis-trans isomerase NIMA-interacting protein 1 (Pin1) is an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Pin1 displays a preference for an acidic residue N-terminal to the isomerized proline bond, catalyzing pSer/Thr-Pro cis/trans isomerizations [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13526].
UniGene ID
Hs.465849
UniProt ID (eCommerce)
Q13526

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.