human OAS1 Adenovirus
This is an Adenovirus expressing Human OAS1.
ADV-217305
Ad-h-OAS1
Ready-to-use Adenovirus expressing Human OAS1 (2′-5′-oligoadenylate synthetase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
E18/E16; IFI-4; OIAS; OIASI
Description (Vector)
OAS1 encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.
Gene ID
4938
Gene Name (Vector)
2'-5'-oligoadenylate synthetase 1
Gene Symbol
OAS1
HGNC ID
HGNC:8086
ORF Size (aa)
1095
ORF Size (bp)
1095 bp
RefSeq ID
NM_002534
RefSeq Synonyms
NM_016816, NM_002534, NM_001320151, NM_001032409, BC071981, BC061587, BC000562,
Species
human
UniGene ID
Hs.524760
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.