human ACTA2 Over-expression AAV

Name 
AAV-h-ACTA2
Cat No 
AAV-200268
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ACTA2.

AAV-200268
AAV-h-ACTA2

Ready-to-use AAV expressing Human ACTA2 (actin, alpha 2, smooth muscle, aorta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
actin, aortic smooth muscle; ACTSA; Alpha-actin-2; alpha-cardiac actin; cell growth-inhibiting gene 46 protein
Description (eCommerce)
Alpha Smooth Muscle Actin is one of six different actin proteins, all of which are highly conserved and involved in cell motility, structure, integrity, and intercellular signaling. Alpha Smooth Muscle Actin is involved in vascular contractility and blood pressure homeostasis. [taken from NCBI Entrez Gene (Gene ID: 59)].
Description (Vector)
ACTA2 belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Gene ID
59
Gene Name (eCommerce)
actin, alpha 2, smooth muscle, aorta
Gene Name (Vector)
actin, alpha 2, smooth muscle, aorta
Gene Symbol
ACTA2
HGNC ID
HGNC:130
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1134
ORF Size (bp)
1134 bp
Protein Name (eCommerce)
Actin, aortic smooth muscle
RefSeq ID
NM_001613
RefSeq Synonyms
NM_001613, NM_001320855, NM_001141945, BC093052, BC017554,
Research Areas
Cardiovascular,Cytoskeleton,EGFR Signaling,Host-Virus Interactions,PDGF Signaling,Response to Virus,Signal Transduction
Research Areas (Faceted)
cardiovascular,cell_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
Alpha Smooth Muscle Actin is one of six different actin proteins, all of which are highly conserved and involved in cell motility, structure, integrity, and intercellular signaling. Alpha Smooth Muscle Actin is involved in vascular contractility and blood pressure homeostasis. [taken from NCBI Entrez Gene (Gene ID: 59)].
UniGene ID
Hs.500483
UniProt ID (eCommerce)
P62736

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.