human MBD3 Adenovirus

Name 
Ad-h-MBD3
Cat No 
ADV-215089
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human MBD3.

ADV-215089
Ad-h-MBD3

Ready-to-use Adenovirus expressing Human MBD3 (methyl-CpG binding domain protein 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3
Description (eCommerce)
Methyl-CpG binding domain protein 3 (MBD3) is a subunit of the NuRD complex and plays a role in recruiting histone deacetylases and DNA methyltransferases to DNA for transcriptional repression.
Description (Vector)
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.
Gene ID
53615
Gene Name (eCommerce)
methyl-CpG binding domain protein 3
Gene Name (Vector)
methyl-CpG binding domain protein 3
Gene Symbol
MBD3
HGNC ID
HGNC:6918
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
780
ORF Size (bp)
780 bp
Protein Name (eCommerce)
Methyl-CpG-binding domain protein 3
RefSeq ID
NM_003926
RefSeq Synonyms
NM_003926, NM_001281454, NM_001281453, BC043619, BC009372,
Research Areas
Breast Cancer,Cancer,Histone Modification,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,transcription_translation
Species
human
Target Sentence
Methyl-CpG binding domain protein 3 (MBD3) is a subunit of the NuRD complex and plays a role in recruiting histone deacetylases and DNA methyltransferases to DNA for transcriptional repression.
UniGene ID
Hs.178728
UniProt ID (eCommerce)
O95983

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.