human ACO1 Over-expression AAV

Name 
AAV-h-ACO1
Cat No 
AAV-200198
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ACO1.

AAV-200198
AAV-h-ACO1

Ready-to-use AAV expressing Human ACO1 (aconitase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1
Description (Vector)
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
Gene ID
48
Gene Name (Vector)
aconitase 1
Gene Symbol
ACO1
HGNC ID
HGNC:117
ORF Size (aa)
2670
ORF Size (bp)
2670 bp
RefSeq ID
NM_002197
RefSeq Synonyms
NM_002197, NM_001278352, BC018103,
Species
human
UniGene ID
Hs.567229

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.