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human PPP2R5C Adenovirus

Name 
Ad-h-PPP2R5C
Cat No 
ADV-214162
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PPP2R5C.

ADV-214162
Ad-h-PPP2R5C

Ready-to-use Adenovirus expressing Human PPP2R5C (protein phosphatase 2 regulatory subunit B’, gamma). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
B' alpha regulatory subunit; B56G; B56gamma; PP2A B subunit isoform B56-gamma; PP2A B subunit isoform B'-gamma; PP2A B subunit isoform PR61-gamma; PP2A B subunit isoform R5-gamma; PR61G; protein phosphatase 2 regulatory subunit B', gamma; protein phosphatase 2, regulatory subunit B (B56), gamma isoform; protein phosphatase 2, regulatory subunit B', gamma isoform; renal carcinoma antigen NY-REN-29; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Description (eCommerce)
Protein phosphatase 2, regulatory subunit B', gamma (PPP2R5C) is a regulatory subunit of the PP2A phosphatase. The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13362].
Description (Vector)
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
5527
Gene Name (eCommerce)
protein phosphatase 2 regulatory subunit B'gamma
Gene Name (Vector)
protein phosphatase 2 regulatory subunit B', gamma
Gene Symbol
PPP2R5C
HGNC ID
HGNC:9311
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1155
Protein Name (eCommerce)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
RefSeq ID
NM_002719
RefSeq Synonyms
NM_178587, NM_178586, NM_002719, NM_001161726, NM_001161725, BC016183,
Research Areas
Apoptosis,Cell Cycle,DNA Damage/Repair,Immunology,Kinase/Phosphatase,Meiosis,Metabolism/Metabolic Process,Neurobiology,PI3K/Akt Signaling,Signal Transduction,Wnt Signaling
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,immunology,cell_biology,cell_cycle,metabolism,neurobiology,signal_transduction,developmental_biology
Species
human
Target Sentence
Protein phosphatase 2, regulatory subunit B', gamma (PPP2R5C) is a regulatory subunit of the PP2A phosphatase. The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13362].
UniGene ID
Hs.710260
UniProt ID (eCommerce)
Q13362

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.