Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human PHLPP2 Adenovirus

Name 
Ad-h-PHLPP2
Cat No 
ADV-214159
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PHLPP2.

ADV-214159
Ad-h-PHLPP2

Ready-to-use Adenovirus expressing Human PHLPP2 (PH domain and leucine rich repeat protein phosphatase 2). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
PH domain leucine-rich repeat-containing protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPPL; PHLPP-like; PPM3B; protein phosphatase, Mg2+/Mn2+ dependent 3B
Description (eCommerce)
PHLPPL (PH domain leucine-rich repeat-containing protein phosphatase-like) is responsible for the dephosphorylation and subsequent inactivation of Akt. Akt is a signaling protein critical to the balance of cell survival and apoptosis. Dephosphorylation of Akt by PHLPPL has been demonstrated to trigger apoptosis and suppress tumor cell growth. PHLPPL is also known as PHLPPL2 and functions similarly to its relative, PHLPP1. Recent studies show that PHLPPL and PHLPP selectively terminate Akt-signaling by targeting specific Akt isoforms.
Gene ID
23035
Gene Name (eCommerce)
PH domain and leucine rich repeat protein phosphatase 2
Gene Name (Vector)
PH domain and leucine rich repeat protein phosphatase 2
Gene Symbol
PHLPP2
HGNC ID
HGNC:29149
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3972
ORF Size (bp)
3972 bp
Protein Name (eCommerce)
PH domain leucine-rich repeat-containing protein phosphatase 2
RefSeq ID
NM_015020
RefSeq Synonyms
NM_015020, NM_001289003, BC129927,
Research Areas
B-cell Receptor Signaling,Cancer,EGFR Signaling,EGFR Signaling in Cancer,Fc Receptor Signaling,FGF Signaling,Immunology,Innate Immunity,Kinase/Phosphatase,Neurobiology,NGF Signaling,PDGF Signaling,Phosphatase,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,SCF-KIT Signaling,Signal Transduction,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,immunology,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
PHLPPL (PH domain leucine-rich repeat-containing protein phosphatase-like) is responsible for the dephosphorylation and subsequent inactivation of Akt. Akt is a signaling protein critical to the balance of cell survival and apoptosis. Dephosphorylation of Akt by PHLPPL has been demonstrated to trigger apoptosis and suppress tumor cell growth. PHLPPL is also known as PHLPPL2 and functions similarly to its relative, PHLPP1. Recent studies show that PHLPPL and PHLPP selectively terminate Akt-signaling by targeting specific Akt isoforms.
UniGene ID
Hs.531564
UniProt ID (eCommerce)
Q6ZVD8

Recently Viewed Products

AAV-r-CEACAM11

Cat No: AAV-294019

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.