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human LIFR Adenovirus

Name 
Ad-h-LIFR
Cat No 
ADV-213919
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human LIFR.

ADV-213919
Ad-h-LIFR

Ready-to-use Adenovirus expressing Human LIFR (leukemia inhibitory factor receptor alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD antigen CD118; CD118; CD118 antigen; leukemia inhibitory factor receptor; leukemia inhibitory factor receptor alpha; LIF receptor; LIF-R; SJS2; STWS; SWS
Description (eCommerce)
Leukemia inhibitory factor receptor (LIFR) is a signal-transducing molecule. LIFR may have a common pathway with IL6ST. The soluble form of LIFR inhibits the biological activity of LIF by blocking its binding to receptors on target cells [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P42702].
Description (Vector)
LIFR encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.
Gene ID
3977
Gene Name (eCommerce)
LIF receptor alpha
Gene Name (Vector)
leukemia inhibitory factor receptor alpha
Gene Symbol
LIFR
HGNC ID
HGNC:6597
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3294
ORF Size (bp)
3294 bp
Protein Name (eCommerce)
Leukemia inhibitory factor receptor
RefSeq ID
NM_002310
RefSeq Synonyms
NM_002310, NM_001127671, BC153096, BC141428,
Research Areas
Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,JAK-STAT Signaling,Leukemia,Neurobiology,Neurodevelopment,Signal Transduction
Research Areas (Faceted)
cancer,cardiovascular,developmental_biology,neurobiology,signal_transduction
Species
human
Target Sentence
Leukemia inhibitory factor receptor (LIFR) is a signal-transducing molecule. LIFR may have a common pathway with IL6ST. The soluble form of LIFR inhibits the biological activity of LIF by blocking its binding to receptors on target cells [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P42702].
UniGene ID
Hs.133421
UniProt ID (eCommerce)
P42702

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.