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human KANK1 Adenovirus

Name 
Ad-h-KANK1
Cat No 
ADV-212617
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human KANK1.

ADV-212617
Ad-h-KANK1

Ready-to-use Adenovirus expressing Human KANK1 (KN motif and ankyrin repeat domains 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ANKRD15; ankyrin repeat domain-containing protein 15; CPSQ2; KANK; kidney ankyrin repeat-containing protein; KN motif and ankyrin repeat domain-containing protein 1
Description (eCommerce)
The gene that encodes KANK1 (KN motif and ANKyrin repeat-domain-containing protein 1) was originally identified in a chromosomal region that exhibited loss of heterozygosity in renal cell carcinoma. KANK1 bears five ankyrin repeats and a conserved motif at the N-terminus which contains motifs for nuclear localization and export signals (KN-motif). It functions to regulate actin stress fiber formation and has been found to be a substrate of Akt and to bind 14-3-3.
Description (Vector)
KANK1 belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseuodgene has been identified on chromosome 20.
Gene ID
23189
Gene Name (eCommerce)
KN motif and ankyrin repeat domains 1
Gene Name (Vector)
KN motif and ankyrin repeat domains 1
Gene Symbol
KANK1
HGNC ID
HGNC:19309
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4059
ORF Size (bp)
4059 bp
Protein Name (eCommerce)
KN motif and ankyrin repeat domain-containing protein 1
RefSeq ID
NM_015158
RefSeq Synonyms
NM_153186, NM_015158, NM_001256877, NM_001256876, BC038116, BC037495,
Research Areas
Cancer,Cytoskeleton,Insulin Signaling,Neurobiology,Neurodevelopment,Rho Signaling,Signal Transduction,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
The gene that encodes KANK1 (KN motif and ANKyrin repeat-domain-containing protein 1) was originally identified in a chromosomal region that exhibited loss of heterozygosity in renal cell carcinoma. KANK1 bears five ankyrin repeats and a conserved motif at the N-terminus which contains motifs for nuclear localization and export signals (KN-motif). It functions to regulate actin stress fiber formation and has been found to be a substrate of Akt and to bind 14-3-3.
UniGene ID
Hs.306764
UniProt ID (eCommerce)
Q14678

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.