Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human ITGB4 Adenovirus

Name 
Ad-h-ITGB4
Cat No 
ADV-212511
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ITGB4.

ADV-212511
Ad-h-ITGB4

Ready-to-use Adenovirus expressing Human ITGB4 (integrin subunit beta 4). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD antigen CD104; CD104; CD104 antigen; GP150; integrin beta-4
Description (eCommerce)
The gene ITGB4, also known as CD104, encodes for the integrin beta subunit integrin beta-4. Integrin alpha-6/beta-4 is a receptor for laminin and plays a critical structural role in the hemidesmosome of epithelial cells. ITGA6:ITGB4 is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in ITGB4/CD104 are associated with epidermolysis bullosa with pyloric atresia [taken from NCBI Entrez Gene (Gene ID: 3691) and UniProtKB (Entry: P16144)].
Description (Vector)
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Gene ID
3691
Gene Name (eCommerce)
integrin subunit beta 4
Gene Name (Vector)
integrin subunit beta 4
Gene Symbol
ITGB4
HGNC ID
HGNC:6158
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5259
ORF Size (bp)
5259 bp
Protein Name (eCommerce)
Integrin beta-4
RefSeq ID
NM_000213
RefSeq Synonyms
NM_001321123, NM_001005731, NM_001005619, NM_000213, BC143742, BC143738, BC126411, BC118916,
Research Areas
Cardiology,Cardiomyopathy,Cardiovascular,Cytoskeleton,EGFR Signaling,PI3K/Akt Signaling,Signal Transduction
Research Areas (Faceted)
cardiovascular,cell_biology,signal_transduction
Species
human
Target Sentence
The gene ITGB4, also known as CD104, encodes for the integrin beta subunit integrin beta-4. Integrin alpha-6/beta-4 is a receptor for laminin and plays a critical structural role in the hemidesmosome of epithelial cells. ITGA6:ITGB4 is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in ITGB4/CD104 are associated with epidermolysis bullosa with pyloric atresia [taken from NCBI Entrez Gene (Gene ID: 3691) and UniProtKB (Entry: P16144)].
UniGene ID
Hs.632226
UniProt ID (eCommerce)
P16144

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.